Hexarelin

Hexarelin is GHRP-6 with a methyl group on the tryptophan, making it more stable and more potent. It acts at the ghrelin receptor to release GH, and in people also drives ACTH and cortisol, apparently through vasopressin. A separate cardiac binding site (CD36) is proposed to explain its effects on heart tissue in animals.

Sequence: His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH₂GHRP-6 with 2-methyl-D-tryptophan in position 2. Three-letter form; no one-letter equivalent.

One claim per card, each with its own tier and source. Tiers 1 and 2 are human data. Tiers 3 and 4 are not yet.

• Two or three daily injections raised 24-hour GH secretion in healthy men without changing IGF-1, prolactin, ACTH or cortisol over one day.

  T2Clinical
  [1]Maccario et al., 2002 (Eur J Endocrinol)(opens in a new tab)

• Produced higher peak GH than insulin-induced hypoglycemia as a test of pituitary reserve in patients with pituitary disease.

  T2Clinical
  [2]Korbonits et al., 1999 (Clin Endocrinol)(opens in a new tab)

• Protected isolated rat hearts from calcium-paradox damage, an effect GH itself did not reproduce.

  T3Preclinical
  [3]Torsello et al., 2001 (Endocrine)(opens in a new tab)

1. [1]Maccario et al., 2002 (Eur J Endocrinol) (opens in a new tab)
2. [2]Korbonits et al., 1999 (Clin Endocrinol) (opens in a new tab)
3. [3]Torsello et al., 2001 (Endocrine) (opens in a new tab)

• IpamorelinT2Clinical

  Ghrelin-receptor / GH secretagogue

  The selective GH pulse without the cortisol baggage.

  2 of 4 claims human-tested · 3 references · Research-only

• GHRP-6T2Clinical

  Ghrelin-receptor / GH secretagogue

  The unnatural peptide that led researchers to ghrelin.

  2 of 3 claims human-tested · 3 references · Research-only

• GHRP-2T2Clinical

  Ghrelin-receptor / GH secretagogue

  The GH-releasing peptide that became a diagnostic test in Japan.

  2 of 2 claims human-tested · 2 references · Approved abroad

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